Conformation–activity relationships of polyketide natural products
نویسندگان
چکیده
منابع مشابه
Polyketide synthase genes and the natural products potential of Dictyostelium discoideum
MOTIVATION The genome of the social amoeba Dictyostelium discoideum contains an unusually large number of polyketide synthase (PKS) genes. An analysis of the genes is a first step towards understanding the biological roles of their products and exploiting novel products. RESULTS A total of 45 Type I iterative PKS genes were found, 5 of which are probably pseudogenes. Catalytic domains that ar...
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Aplydactone (1) is a brominated ladderane sesquiterpenoid that was isolated from the sea hare Aplysia dactylomela together with the chamigranes dactylone (2) and 10-epi-dactylone (3). Given the habitat of A. dactylomela, it seems likely that 1 is formed from 2 through a photochemical [2 + 2] cycloaddition. Here, we disclose a concise synthesis of 1, 2, and 3 that was guided by excited state the...
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[reaction: see text] The conjugate addition of dithiols to bis-ynones generates a versatile masked 1,3,5-triketone platform. These functional units are useful intermediates for the synthesis of oxygen-containing heterocycles commonly found in polyketide natural products. The tetrahydropyranyl fragments of the marine macrolides Lyngbouilloside and Callipeltoside A have been synthesized with use ...
متن کاملMultiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.
The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product portends the generation of novel organic compounds-"unnatural" natural products-by genetic manipula...
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ژورنال
عنوان ژورنال: Natural Product Reports
سال: 2015
ISSN: 0265-0568,1460-4752
DOI: 10.1039/c5np00014a